Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. Jacksonville / Northeast Florida
  4. Jacksonville
  5. Jacksonville
M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.8
4.8
455 Reviews
$50 and over
Seafood

Make a reservation

2 people
7:00 PM
Booked 5 times today
Experiences are available.
  • Good for special occasions
  • Innovative
  • Good for business meals
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

Experiences

  • 12/21 Japan "Grows Together/Goes Together"

    $90.00 - $135.00 per person

    Dec 21, 2024 only
    Join us at M Brothers on Saturday, December 21, 2024, for an unforgettable culinary experience! Indulge in a 4-course tasting menu inspired by the vibrant flavors of Japan! This experience is priced at $90 per person, or elevate your experience with wine pairings for each course for $135. This special menu will ONLY be available December 21st.
    12/21 Japan "Grows Together/Goes Together" Photo

What 455 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.8
4.8 based on recent ratings
  • 4.8Food
  • 4.8Service
  • 4.6Ambience
  • 4.5Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Best Overall

  • Jacksonville / Northeast Florida

    Best Service

  • Jacksonville / Northeast Florida

    Innovative

  • Jacksonville / Northeast Florida

    Healthy

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Overall

  • Jacksonville

    Best Food

  • Jacksonville

    Best Service

  • Jacksonville

    Best Value

  • Jacksonville

    Innovative

  • Jacksonville

    Healthy

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience right in the heart of Mayo Clinic. Guests rave about the "outstanding" food and service, praising the innovative menu and accommodating staff. The ambiance is both calming and inviting, making it a "hidden gem" for any occasion. A must-visit!

455 Reviews
  1. Ellwood

    New York City

    14 reviews

    vip
    5.0

    14 reviews

    Dined 7 days ago

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 4
    The monthly food/wine tastings are exceptional. We never miss them. Morocco cuisine is just not my favorite. While the preparation and quality is excellent, I have never been a big fan of the spices particular to the area. The saxophonist played well, but it was a little loud.

    Is this helpful?

  2. Helen

    London

    37 reviews

    5.0

    37 reviews

    Dined on November 21, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Dining at M Brothers is consistently great! Food is always delicious and perfectly prepared. The menu is filled with things we enjoy eating. And it is all served and delivered by your delightful team. Destiny is a worthy and engaging ambassador. I always look forward to seeing her. Makes the experience that much more special. M Brothers is a true gem.

    Is this helpful?

  3. Margaret

    Calgary

    3 reviews

    vip
    5.0

    3 reviews

    Dined on November 20, 2024

    1. Overall 5
    2. Food 5
    3. Service 3
    4. Ambience 4
    Wonderful food!! So convenient to have an outstanding and high quality restaurant at Mayo.

    Is this helpful?

  4. Cristina

    Jacksonville

    1 review

    4.0

    1 review

    Dined on November 19, 2024

    1. Overall 4
    2. Food 5
    3. Service 4
    4. Ambience 3
    Risotto special was amazing !!!! Service was great. Amazing homemade bread

    Is this helpful?

  5. Melissa

    Atlanta Metro

    28 reviews

    vip
    5.0

    28 reviews

    Dined on November 11, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Jordan was a delight as a server and guide to all your wonderful dishes. I will miss the roasted beet salad as you are changing menus but look forward to your new menu in January when I return.

    Is this helpful?

  6. Jeannie

    Denver

    2 reviews

    5.0

    2 reviews

    Dined on November 9, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Fabulous food. Lovely pottery dishes. Great wait staff! Great bread

    Is this helpful?

  7. Racheal

    Jacksonville

    5 reviews

    vip
    3.0

    5 reviews

    Dined on November 8, 2024

    1. Overall 3
    2. Food 3
    3. Service 4
    4. Ambience 4
    Our server was attentive and kind. Our food took too long to come out from the kitchen. Luckily, our group enjoys spending time with each other.

    Is this helpful?

  8. kayla

    Jacksonville

    1 review

    5.0

    1 review

    Dined on November 4, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Brandon and Dwayne were amazing. Brandon made me a fabulous Dirty Martini and Dwayne recommended two very good bottles of wine for the half off wine Monday. Destanee was a great server and also recommended the Summer Truffle Tagliatelle and Steak Frites. Doug and Dalvin also stopped by our table to make sure everything came out good. Chef Thomas prepared an amazing dessert and all the food was awesome.
    M Brothers at MayoResponded on November 5, 2024
    Thank you for the kind words! We're so glad to hear Brandon, Dwayne, Destinee, Doug, Dalvin, and Chef Thomas all made your experience memorable. We’ll be sure to pass along your compliments to the team. Hope to see you again soon!

    Is this helpful?

  9. Melanie

    Coastal Georgia

    2 reviews

    5.0

    2 reviews

    Dined on October 31, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    The food here is outstanding. I had to stay on the Mayo campus for several days due to a procedure, and it was so uplifting to be able to go to a 4 star restaurant during my recovery process. The atmosphere was very relaxing and beautiful, the service was impeccable, and my entree, the Salmon Nicoise, was delicious. They also have an extensive wine menu, cocktail menu, and delicious desserts.

    Is this helpful?

  10. max

    Miami

    59 reviews

    vip
    5.0

    59 reviews

    Dined on October 22, 2024

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Great staff and food always fresh. Ordered the burrata, shrimp po boy and hamburger they were delicious
    M Brothers at MayoResponded on October 23, 2024
    Thank you for the kind words! Our team looks forward to serving you again soon!

    Is this helpful?

FAQs

M Brothers at Mayo is rated 4.8 stars by 455 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a reservation

2 people
7:00 PM
Booked 5 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Neighborhood
    Jacksonville
  • Hours of operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo