Best Southwest American Restaurants in Medical Center

Price

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$$$
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Regions

Golden CrescentSan Antonio

Neighborhoods

Alamo HeightsDowntownLa CanteraLeon SpringsMedical CenterNorth Central

Top Rated

CharmingFancyGood for business mealsGood for groupsGood for special occasionsGreat for brunch

Dining Options

All dining options

Delivery only

Takeout only

Seating Options

BarCounterStandardHigh TopOutdoor

Accessibility

Gender-neutral restroomWheelchair access

96 restaurants available nearby

1. Clementine

4.9

Exceptional(540)

$$$$Price: Very Expensive

• Mexican • North Central

Booked 29 times today

Clementine, nestled in the heart of North Central, Castle Hills, offers an exquisite journey into Contemporary French/American cuisine, delighting diners with seasonal and innovative dishes. The restaurant, led by Chef John, a 2023 James Beard nominee, consistently wows with its ever-evolving menu and crowd favorites like the Ricotta Cavatelli and Clementine Crunch Bar. Guests rave about the "Feed Me" option, an adventurous five-course experience that "never disappoints" with its "multilayered flavors" and "superb" surprises. The vibrant ambiance, coupled with an expertly curated selection of wines, ensures a dining experience that is both authentic and unforgettable. Clementine truly stands out as one of San Antonio's top culinary destinations.

A photo of Tu Asador - Castle Hills restaurant

2. Tu Asador - Castle Hills

4.6

Exceptional(161)

$$$$Price: Expensive

• Mexican • North Central

Booked 4 times today

Tu Asador - Castle Hills is a top-notch Mexican Steakhouse that takes you on a culinary journey through Northern Mexico's rich flavors. Known for its "authentic representation of flavors passed down through generations," Tu Asador makes dining an experience rather than just a meal. Patrons rave about the "superb food" and "attentive service," with many highlighting the perfectly cooked steaks that are "juicy, flavorful, and made with quality beef." The vibrant atmosphere, complete with live music, enhances the experience, making it a "fun ambiance" for any occasion. It's no surprise that Tu Asador is a favorite among locals and newcomers alike.

A photo of Alamo Biscuit Company & Panaderia restaurant

3. Alamo Biscuit Company & Panaderia

4.3

Awesome(10)

$$$$Price: Moderate

• Mexican • Northwest

Booked 1 time today

*For reservations over 12, please contact us directly at 210-204-8520. *On the weekend, we only take reservations for parties of 6-12, for questions please contact us directly 210-204-8520.Great hospitality is an extension of great service, taking it to another level. Here at Alamo Biscuit Co., hospitality is a great dining experience that goes far beyond great food and great service. A truly great dining experience is when our guest’s needs are anticipated and met for them, resulting in 100% satisfaction. Our goal is to always strive to make every moment memorable.

A photo of 54th Street Restaurant & Drafthouse - The Colonnade restaurant

4. 54th Street Restaurant & Drafthouse - The Colonnade

(0)

$$$$Price: Moderate

• Mexican • Medical Center

54th Street was founded in Kansas City, MO by Thomas E. Norsworthy in 1989. He envisioned a place that would accommodate a consistently crowded dining room as well as a lively bar crowd, while offering the quality food and drinks that exceed national chain competitors. At 54th Street, we believe that great food starts with fresh produce, high quality meats and ingredients and meals prepared from scratch. With our amazing range of scratch prepared menu items, we truly have something for everyone. The Five-Four promise is to forever uphold our tradition of serving generous portions of housemade food and drink at an honest price. 54th Street welcomes you for all occasions. Drop in for Happy Hour with friends, celebrate a special occasion, enjoy a family night out or fly solo! Ultimately, it’s your time. Join us, experience 54 and share the 54 experience with others.

A photo of Dave & Buster's - San Antonio (Balcones Heights) restaurant

5. Dave & Buster's - San Antonio (Balcones Heights)

4.6

Exceptional(108)

$$$$Price: Moderate

• Mexican • Medical Center

Booked 4 times today

Each Dave & Buster’s has more state-of-the-art games than ever, more mouth-watering menu items and the most innovative drinks anywhere. From wings to steaks, we’ve got whatever suits your appetite and our premium bar assures we’re stocked to satisfy! Plus, you can watch your game on one of our massive HDTVs with epic stadium sound.

6. Kona Grill - North Star

4.3

Awesome(595)

$$$$Price: Moderate

• Mexican • North San Antonio

Booked 1 time today

Kona Grill - North Star is a sushi lover's paradise nestled in the vibrant North San Antonio area. Renowned for its "award-winning sushi," this restaurant offers an authentic Japanese dining experience with a touch of contemporary flair. The sushi menu is crafted with precision, using only the freshest ingredients, ensuring each bite is a taste revelation. The Tuna Tartar and the special traditional rolls, described as "10/10!!!" by customers, are must-tries that highlight the exceptional quality and artistry behind each dish. With a polished yet casual atmosphere and impeccable service, Kona Grill is the perfect spot for sushi enthusiasts seeking both quality and authenticity.

A photo of Rock & Brews - San Antonio restaurant

7. Rock & Brews - San Antonio

4.4

Awesome(23)

$$$$Price: Moderate

• Mexican • North Central

Booked 2 times today

We have it all! American food, craft beers, signature cocktails, large parties and private dining space, live music, catering, live sports, dog-friendly patios, and more! Rock your taste buds with our American inspired menu boasting creative spins on the standards. Our menu items are prepared from scratch using fresh ingredients from the local community. Wash down our culinary creations with one of our 48+ craft beers on tap from local, national, and international breweries or check out our signature cocktails and extensive bourbon and tequila selections! The restaurant can accommodate sports fanatics and large parties of any size (including family and corporate gatherings, youth sports teams, and rehearsal dinners) in our sizable dining room or on our private patios. The restaurant also features live music, weekday lunch specials, a dog-friendly outdoor patio (ask to see our dog menu), and brunch on the weekends.

A photo of Red Lobster - San Antonio - NW Loop 410 restaurant

8. Red Lobster - San Antonio - NW Loop 410

4.4

Awesome(18)

$$$$Price: Moderate

• Mexican • North San Antonio

Elevate your day at Red Lobster, where fun meets fancy and every meal is a celebration. Whether you’re marking a special occasion or treating yourself or your crew, Red Lobster is the perfect place to enjoy all your seafood favorites. Dive into our signature shrimp, wild caught lobster and crab, and more. Plus, a variety of fish and popular non-seafood items like our Cajun Chicken Linguini Alfredo. Looking for a showstopper? Create Your Own Ultimate Feast or select a Live Maine Lobster straight from the tank. Or explore our Daily Deals with a different special available each weekday at a price you’ll love. Toast the day with Signature Cocktails including Lobster Punch and Main Deck Margarita Flights to make any moment feel festive. You won’t want to miss our newest menu items or special promotions like Lobsterfest and Crabfest. Reserve online today. Group Dining, To Go, or Catering options. For parties of 11+, please call.

A photo of Pinstack - San Antonio - Park North restaurant

9. Pinstack - San Antonio - Park North

3.9

Excellent(27)

$$$$Price: Moderate

• Mexican • Victoria

Booked 2 times today

Reservations are available in our full-service restaurant or climate-controlled patio. TO ENJOY LANE-SIDE SERVICE WHILE YOU BOWL, RESERVATIONS ARE AVAILABLE AT https://pinstackbowl.com/reserve-lane/. PINSTACK is an upscale, one-of-a-kind entertainment and dining destination. Featuring dishes from pan-seared mahi mahi to our GIANT 36-inch KingPin Pizza, everyone will enjoy eating at PINSTACK. With two fully-stocked bars, PINSTACK is a favorite spot for adults. Choose from 24 draft beers, 12 keg wines, and an extensive list of bottled wine & craft cocktails. The PINSTACK experience doesn't end after dinner! Have fun on the bowling lanes or in the game room, featuring video games, rock climbing wall, high ropes course, laser tag or bumper cars. Weekly Specials: Happy Hour |M-F 4-7 pm | $3 Domestic Pints | $5 Craft Pints | $5 House Wine | $5 House Margaritas Bowl & Bite Mondays | 4-11 pm | 1/2 Price Apps | $3 Draft Beer Wine Down Wednesdays | ALL DAY | 50% off bottles

A photo of Haywire - La Cantera restaurant

10. Haywire - La Cantera

4.5

Awesome(244)

$$$$Price: Expensive

• Mexican • La Cantera

Booked 105 times today

Haywire - La Cantera in San Antonio is redefining the Cocktail Bar experience with its exceptional collection of highly allocated whiskeys and inventive cocktail creations. Guests rave about the "Vaquero and haywire old-fashioned," describing them as "top-notch" and perfect for an upscale night out. The rustic yet elegant atmosphere complements the expertly crafted drinks, creating a warm and inviting setting for any occasion. The attentive staff ensures a memorable visit, with one review highlighting a bartender who was "perfect" and contributed to a "relaxed but elegant" atmosphere. Haywire's cocktail offerings promise an unforgettable taste of Texas hospitality.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you

A
Ashley
Dallas - Fort Worth •5 reviews
5.0
Dined today
Second time here and the food, drinks, and service was still so good!
More info
Domingo RestaurantePrice: Expensive• Mexican / Southwestern• Downtown
•
4.5
C
christina
Denver / Colorado •8 reviews
4.0
Dined 1 day ago
Disappointed in the menu change. Food was good but it was better before with a bigger selection before the change. Also, I wish the staff would have been more mindful of 3 kids at table and I would’ve appreciated suggest moving spicy ingredients to the side. Also, rice on kids menu was spicy. This is a second visit.
More info
MezquitePrice: Moderate• Northern Mexican• Downtown
•
4.6
H
Heather
San Antonio •1 review
5.0
Dined 2 days ago
This is our go to when staying in downtown San Antonio. The food is great & they have plenty of gluten free options.
More info
ÁcenarPrice: Moderate• Contemporary Mexican• Downtown
•
4.3
N
Noel
San Antonio •64 reviews
5.0
Dined 5 days ago
Consistently the best TexMex in New Braunfels. Smoked meats, esp brisket, are a specialty and are always excellent. Elevated chiles rellenos are roasted instead of battered and fried and contain high quality ingredients such as brisket or smoked chicken. Queso, beans (both refried and charro) and margaritas are of superior quality to all others we have tried locally. Highly recommend.
More info
Dos Rios Mexican Bar & GrillPrice: Moderate• Mexican• New Braunfels
•
4.5
J
James
San Antonio •3 reviews
5.0
Dined on Feb 9, 2025
The service provider Daniel and food quality combined with unbelievable attention to each customer’s desire is 5 star for this restaurant. Always consistently with their offerings to all ages.
More info
Las Guitarras RestaurantPrice: Moderate• Mexican• Boerne
•
4.6

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