Best Southwest American Restaurants in Clarksville

73 restaurants available nearby

A photo of Red Lobster - Clarksville - Lewis and Clark Parkway restaurant

1. Red Lobster - Clarksville - Lewis and Clark Parkway

4.3

Awesome(15)

Price: Moderate

• Mexican • Clarksville

Booked 2 times today

Elevate your day at Red Lobster, where fun meets fancy and every meal is a celebration. Whether you’re marking a special occasion or treating yourself or your crew, Red Lobster is the perfect place to enjoy all your seafood favorites. Dive into our signature shrimp, wild caught lobster and crab, and more. Plus, a variety of fish and popular non-seafood items like our Cajun Chicken Linguini Alfredo. Looking for a showstopper? Create Your Own Ultimate Feast or select a Live Maine Lobster straight from the tank. Or explore our Daily Deals with a different special available each weekday at a price you’ll love. Toast the day with Signature Cocktails including Lobster Punch and Main Deck Margarita Flights to make any moment feel festive. You won’t want to miss our newest menu items or special promotions like Lobsterfest and Crabfest. Reserve online today. Group Dining, To Go, or Catering options. For parties of 11+, please call.

A photo of River House Restaurant & Raw Bar restaurant

2. River House Restaurant & Raw Bar

4.7

Exceptional(7355)

Price: Moderate

• Mexican • Downtown Louisville

Booked 29 times today

River House Restaurant & Raw Bar in downtown Louisville is a beacon for those seeking top-notch Contemporary American cuisine with a Southern twist. Nestled along the scenic Ohio River, this establishment stands out for its fresh seafood and regional dishes, masterfully crafted by the visionary Chef John Varanese. Diners rave about the "outstanding" food, such as the Maker’s Mark Bourbon Barrel Smoked Salmon and Grilled Oysters on the Half Shell, which showcase the restaurant’s commitment to quality and authenticity. With its "charming home-like atmosphere" and a raw bar that boasts "the best seafood in Louisville," River House provides a dining experience that is both delightful and memorable. Guests consistently praise the attentive service and the "beautiful views," making it a must-visit destination for anyone craving a true taste of Contemporary American excellence.

A photo of Guacamole Modern Mexican restaurant

3. Guacamole Modern Mexican

4.8

Exceptional(1761)

Price: Moderate

• Mexican • East Market St - NuLu

Booked 31 times today

Guacamole Modern Mexican is Louisville’s destination for authentic Mexican cuisine with a modern twist. Our award-winning chefs have created a menu that typifies the best of Mexican food and cocktails while still bringing their own inimitable style and personality to the plate and glass. Immerse yourself in the ambiance of our one of a kind restaurant featuring handcrafted cocktails, fresh ingredients, and contemporary vibes.

4. Proof on Main

4.5

Awesome(3738)

Price: Expensive

• Mexican • Downtown Louisville

Booked 21 times today

The ingredients in our menus reflect the region’s sustainable farmers and producers with a soulful and honest approach showcasing the bounty of the Ohio River Valley. Housed in five historic buildings in downtown Louisville, Proof on Main is part of 21c Museum Hotels, the award-winning boutique hotel and restaurant group. The dining room is one of the most striking public spaces in the city, with rotating, contemporary art exhibitions by local and internationally-acclaimed artists alike.

5. Swizzle

4.5

Awesome(2111)

Price: Expensive

• Mexican • Downtown Louisville

Booked 32 times today

Swizzle, nestled in the vibrant heart of Downtown Louisville, is a premier destination for cocktail enthusiasts. Celebrated for its "sexy, swanky" ambiance and panoramic river views, Swizzle elevates the cocktail bar experience. Guests rave about the "retro tone" of the drink menu, which features meticulously crafted classic cocktails and seasonal specialties. The Swizzle Big Bar area is a social hotspot, offering enticing happy hour specials and delightful bar bites. Reviewers consistently praise the quality of the drinks, like the "spot on" smoky Old Fashioned and the refreshing Sting Like a Bee. With such endorsements and its superb setting, Swizzle is a must-visit for an authentic and memorable cocktail experience in Louisville.

A photo of Vincenzo's Italian Restaurant restaurant

6. Vincenzo's Italian Restaurant

4.8

Exceptional(3684)

Price: Expensive

• Mexican • Downtown Louisville

Booked 29 times today

Vincenzo's Italian Restaurant in Downtown Louisville redefines American dining with its exemplary approach to classic Italian cuisine, prepared with a distinct American flair. Established in 1986 and highly acclaimed, including being named the Best Italian Restaurant in Kentucky by The Daily Meal in May 2020, Vincenzo's embodies the quality and authenticity of American food culture. Diners consistently praise their experiences: "The food was exceptional," and "Service was welcoming, well-timed, and reminiscent of the best classic Italian traditions." The restaurant's commitment to table-side food preparation and flaming specialty desserts further enhances the dining experience, making every visit memorable. As one diner enthusiastically noted, "This is a fabulous restaurant in every regard. My favorite in Louisville, perhaps anywhere!"

A photo of High Stakes Rooftop Grill restaurant

7. High Stakes Rooftop Grill

4.0

Excellent(81)

Price: Expensive

• Mexican • West Louisville

Booked 10 times today

High Stakes is a modern take on the classic American grill showcasing culinary traditions and flavorsome grilling techniques with a dedication to high-quality ingredients. Paying homage to the come-from-behind winners in life, sports, history, and the arts – celebrating all the unimaginable photo finishes, strivers, and unlikely underdog winners that have made this great country what it is today. Here’s to the winners, the higher the stakes, the more you own that moment in time.

A photo of Doc Crow's Southern Smokehouse & Raw Bar restaurant

8. Doc Crow's Southern Smokehouse & Raw Bar

4.4

Awesome(1506)

Price: Moderate

• Mexican • Downtown Louisville

Booked 25 times today

Doc Crow's Southern Smokehouse & Raw Bar in downtown Louisville is a haven for barbecue enthusiasts, offering a delightful fusion of traditional Southern cooking and authentic barbecue flavors. Patrons rave about the "best BBQ I've had in a long time," particularly praising the pulled pork sandwich and the perfectly crafted Old Fashioned. The restaurant's commitment to quality is evident, with visitors noting that the brisket was "the best they'd tasted." Amidst a cozy atmosphere complemented by an extensive bourbon list, Doc Crow's not only promises great food and drinks but also a true taste of Southern hospitality. Whether you're a local or just passing through, Doc Crow's is a must-visit for a memorable barbecue experience.

A photo of Steak & Bourbon - Downtown restaurant

9. Steak & Bourbon - Downtown

4.8

Exceptional(30)

Price: Very Expensive

• Mexican • West Louisville

Booked 49 times today

Steak & Bourbon is a modern steakhouse where the ambiance strikes a perfect balance between elegance and warmth. The walls are adorned in a soft light grey, creating a serene backdrop that allows the luxurious gold trims to shine. The large windows and the sophisticated lighting fixtures, casting a warm glow throughout the space.The dining area features sleek, contemporary furniture with plush, comfortable seating. Tables are dressed with crisp white linens, each set with polished cutlery and carefully curated centerpieces that add a touch of sophistication.The overall atmosphere is inviting yet refined, perfect for both intimate dinners and lively gatherings, making it a destination for steak lovers and food enthusiasts alike.

A photo of Brendon's Catch 23 restaurant

10. Brendon's Catch 23

4.8

Exceptional(3114)

Price: Very Expensive

• Mexican • Downtown Louisville

Booked 6 times today

Brendon's Catch 23 in Downtown Louisville is a culinary gem, particularly celebrated for its Steakhouse offerings. Known for delivering not only the freshest seafood but also prime steaks, this restaurant guarantees a top-quality dining experience. Guests rave about the "perfectly prepared" steaks and the ambiance that complements every meal. With glowing testimonials such as, "the king crab jar was very good and the steak was perfect med rare," it's clear that Brendon's Catch 23 masters the art of steak preparation. Their commitment to quality and service makes every visit memorable, with patrons often noting the exceptional service that makes each dining experience feel special and personalized. Whether you're a local or visiting Louisville, Brendon's Catch 23 promises a steakhouse experience that's both authentic and unforgettable.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

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Best Southwest American Restaurants in Clarksville

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73 restaurants available nearby

1. Red Lobster - Clarksville - Lewis and Clark Parkway

2. River House Restaurant & Raw Bar

3. Guacamole Modern Mexican

4. Proof on Main

5. Swizzle

6. Vincenzo's Italian Restaurant

7. High Stakes Rooftop Grill

8. Doc Crow's Southern Smokehouse & Raw Bar

9. Steak & Bourbon - Downtown

10. Brendon's Catch 23

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